Distal nephron function in patients receiving chronic lithium therapy
نویسندگان
چکیده
منابع مشابه
Distal nephron function of the rat during lithium chloride infusion.
Distal nephron function of the rat during lithium chloride infusion. Chronic lithium (Li) administration in the rat leads to reduced renal concentration (TCH20) without alterations in renal dilution (CH), To examine the acute effects of lithium on TH2O and C1120, rats were infused with a solution composed of 1% sodium chloride and 1% lithium chloride or a 0.225% lithium chloride solution at rat...
متن کاملChronic lithium treatment inhibits amiloride-sensitive sodium transport in the rat distal nephron.
Chronic treatment of rats with lithium leads to Na+ loss and a reduced antinatriuretic response to aldosterone, suggesting that lithium reduces conductive Na+ transport in the distal nephron. This was investigated in the present study by measuring the renal response to aldosterone infusion followed by amiloride in chronically instrumented conscious rats given lithium for 3 to 4 weeks to achieve...
متن کاملA hypothesis linking sodium and lithium reabsorption in the distal nephron.
BACKGROUND A hypothesis is proposed linking Na(+) and Li(+) reabsorption in the distal nephron. The handling of these two ions in the distal nephron is related because they share the same apical membrane entry mechanism: the amiloride-sensitive Na(+) channel (ENaC). However, the two ions exit the cell through different transport mechanisms: Na(+) via the Na(+)-K(+)-ATPase and Li(+) via the Na(+...
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In all neurosurgical cases associated with anticoagulation/antiplatelet therapy, perioperative antithrombotic management of patients is complicated due to increased risks of intraand/or postoperative bleeding or thromboembolic complications. The potential risk of thrombosis may increase when anticoagulation/antiplatelet therapy is stopped perioperatively. On the other hand, perioperative hemorr...
متن کاملGranulocyte function during lithium therapy.
Random migration, chemotaxis, phagocytosis, and bactericidal ability of neutrophils from 5 patients receiving lithium carbonate were compared with those of neutrophils from healthy donors. These cells functioned normally in all respects. Neither sera from patients receiving lithium carbonate nor the addition of lithium chloride to control cells in vitro significantly altered their functional ca...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1982
ISSN: 0085-2538
DOI: 10.1038/ki.1982.49